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virus auto regenerating in appdata/localLow/Microsoft

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Hi, and thanks in advance for your advice.
I couldn't run aswmbr, so no log of that attached. The computer was running Microsoft Security Essentials, but that has been disabled by the virus. There are multiple files being created under *username*/appdata/LocalLow/ . Can't run malwarebytes, or malwarebytes anti-rootkit, or Avast installer, or Eset installer, or Eset online scanner, or ASWMBR.
Has multiple instances of Vrtpbhil.exe running , but not when in safe mode.
Cheers,
David

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